Python DEFI Projects: 263+ Open-Source Examples

Browse 263+ open-source Python DEFI projects from ETHGlobal hackathons. Find production-ready code, learn from winning implementations, and discover inspiration for your next blockchain build.

Browse Python DeFi tools from ETHGlobal events. Get trading bots, yield optimizers, risk analyzers, and data pipelines for decentralized finance analysis.

Alpha Foundry

Decentralized token-gated Web3 data marketplace for trading bots with live DEX analytics

PythonNext.jsdefinftgaming

🏆 Best Consumer DataCoin Created (Lighthouse)

ETHOnline 2025 • 2025

AutoETH

Autonomous agents compete, learn, and evolve to achieve AI-driven decentralized consensus.

SolidityReactTypeScriptPythonNext.jsdefiinfrastructuregaming

ETHOnline 2025 • 2025

cryptexpenso

AI-powered crypto expense management with blockchain integration, approvals and PYUSD reimbursements

ReactTypeScriptPythonPostgreSQLdefinftdaoinfrastructure

ETHOnline 2025 • 2025

DeFlow

AI-powered DeFi workflows with natural language - swap, bridge, and interact.

ReactPythonNode.jsdefiinfrastructureprivacy

🏆 🏆 ETHOnline 2025 Finalist (ETHGlobal)🏆 Best DeFi automation Vincent Apps (Lit Protocol)

ETHOnline 2025 • 2025

Sentinel Oracle

Sentinel Oracle is a privacy-preserving, AI-powered DeFi oracle system

SolidityReactPythonNext.jsdefiinfrastructureprivacy

ETHOnline 2025 • 2025

VeraNode

Decentralized ZKML platform verifying AI model authenticity against tampering & fraud

SolidityPythonPostgreSQLdefiinfrastructure

ETHOnline 2025 • 2025

DashProtocol

Voice-first AI layer executing Web2 financial intents on-chain via secure smart contracts.

SolidityPythondefinftinfrastructureprivacy

ETHOnline 2025 • 2025

SuperioAI

Conversational AI for on-chain analysis and instant cross-chain execution

ReactTypeScriptPythonNext.jsdefinftinfrastructuregamingsocial

ETHOnline 2025 • 2025

MARKOV

Web3 Version Control System for Smart Contracts with AI auditing, Gas optimization and monitoring.

SolidityTypeScriptPythondefidaoinfrastructuregamingsocialprivacy

ETHOnline 2025 • 2025

Syntra

Syntra fuses AI + Hypersync to make blockchain data instantly searchable and smart.

ReactTypeScriptPythonNext.jsNode.jsdefi

🏆 Best AI + Envio Tooling Project (Envio)

ETHOnline 2025 • 2025

Trade

A full-stack decentralized marketplace for AI training data with token-gated access control.

SolidityReactTypeScriptPythonNext.jsNode.jsdefinftdaoinfrastructuregamingprivacy

ETHOnline 2025 • 2025

Defi Portfolio Mngr

Bridge live crypto market data to AI assistants through the Model Context Protocol

Pythondefiinfrastructure

ETHOnline 2025 • 2025

Page 3 of 22 • Showing 12 of 263 projects